IDENTIFICATION OF A NOVEL AP2 TRANSCRIPTION FACTOR IN ZYGOTES WITH AN ESSENTIAL ROLE IN PLASMODIUM OOKINETE DEVELOPMENT.

Identification of a novel AP2 transcription factor in zygotes with an essential role in Plasmodium ookinete development.

The sexual phase of Plasmodium represents a crucial step in malaria transmission, during which these parasites fertilize and form ookinetes to infect mosquitoes.Plasmodium development after fertilization is thought to proceed with female-stored mRNAs until the formation of a retort-form ookinete; thus, transcriptional activity in zygotes has previo

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